BIOSYNTHETIC-STUDIES ON THE ORIGIN OF THE CYCLOHEXANECARBOXYLIC ACID MOIETY OF ANSATRIENIN-A AND OMEGA-CYCLOHEXYL FATTY-ACIDS

Feeding experiments mich [2,6,10,10-H-2(4)]chorismate in Streptomyces collinus (ansatrienin A) and Alicyclobacillus acidocaldarius (omega-cy clohexyl fatty acids), and inhibitor experiments with glyphosate in th e latter organism, have shown that the biosynthesis of cyclohexanecarb oxylic acid branches off from the shikimate pathway at a point prior t o enolpyruvylshikimate 3-phosphate, either at shikimate or shikimate 3 -phosphate.