PULMONARY METASTASES IN PSEUDOMYXOMA PERITONEI SYNDROME

Background. Pseudomyxoma peritonei (PMP) is a rare disease arising fro m a mucinous cystadenoma of appendiceal origin. The syndrome has been characterized by progressive growth of mucinous tumors, tense mucinous ascites, and ultimately death. Abdominal and pelvic recurrence after resection of intraperitoneal disease occurs in all patients unless adj unctive measures ate taken. Local spread of PMP by direct extension to the pleural or pericardial space is uncommon but has been reported in the literature. Here we report development of pulmonary parenchymal m etastases after treatment for PMP. Methods. The charts of 3 patients w ere retrospectively reviewed for the presentation and management of me tastatic PMP. Results. Three patients underwent resection for pulmonar y parenchymal metastases of PMP, All patients recovered uneventfully. They continue to do well after 2 to 8 years of follow-up. Conclusions. Pulmonary metastasectomy for PMP is safe and effective after treatmen t of intraperitoneal disease.