The interactive etiological and pathogenic processes between physical
and psychosocial environ-mental stimuli, the individual's appraisal of
these influences, and his or her reactions to them in terms of emotio
n, cognition, behaviour, and physiology; the modification of these rea
ctions through coping, social support, and other interacting variables
; and the resulting changes in health and well-being - are extremely c
omplex and poorly understood. Against this background, this paper argu
es for a biopsychosocial approach, based on an ecological model influe
nced by, and influencing, James P. Henry's related approaches. This ap
proach is exemplified in six studies carried out by our group and brie
fly reviewed in this paper.