LOW-DOSE ASPIRIN FOR OOCYTE DONATION RECIPIENTS WITH A THIN ENDOMETRIUM - PROSPECTIVE, RANDOMIZED STUDY

Objective: To evaluate the effect of low-dose aspirin use in oocyte do nation recipients with an endometrial thickness of <8 mm. Design: A pr ospective, randomized study. Setting: An oocyte donation program in a private infertility practice. Patient(s): Twenty-eight recipients unde rgoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle. Intervention(s): Fift een recipients received low-dose aspirin (81 mg/d) in addition to stan dard hormone replacement for an oocyte donation cycle. The remaining 1 3 recipients did not receive aspirin. Main Outcome Measure(s): Clinica l pregnancy rates, delivery rates, implantation rates, and change in e ndometrial thickness were compared in the aspirin and nonaspirin group s. Result(s): There was no demonstrable increase in endometrial thickn ess in the aspirin-treated group. However, there was a statistically s ignificant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rate s in the aspirin-treated group when the final endometrial thickness wa s <8 mm. Conclusion(s): Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium. (C) 1997 by American Society for Reproductive Medicine.