CARBIMAZOLE INDUCED AGRANULOCYTOSIS - RESCUE WITH HUMAN RECOMBINANT GRANULOCYTE-COLONY-STIMULATING FACTOR

Authors
OHARE JA AZHER T
Citation
Ja. Ohare et T. Azher, CARBIMAZOLE INDUCED AGRANULOCYTOSIS - RESCUE WITH HUMAN RECOMBINANT GRANULOCYTE-COLONY-STIMULATING FACTOR, Irish journal of medical science, 166(4), 1997, pp. 239-240
Citations number
7
Categorie Soggetti
Medicine, General & Internal
Journal title
Irish journal of medical science → ACNP
ISSN journal
00211265
Volume
166
Issue
4
Year of publication
1997
Pages
239 - 240
Database
ISI
SICI code
0021-1265(1997)166:4<239:CIA-RW>2.0.ZU;2-0
Abstract
We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she develope d agranulocytosis (64 x 10(6)/l). With 4 days treatment with recombina nt human Granulocyte Colony Stimulating factor the granulocyte count r ose to normal similar to 4,350 cells X 10(6)/l. This is considerably f aster than the rate of spontaneous recovery which usually takes one to 2 weeks.