A PRACTICAL ROUTE TO OPTICALLY-ACTIVE CBI, A POTENT ANALOG OF THE CC-1065 ALKYLATION SUBUNIT

Authors
LING L XIE Y LOWN JW
Citation
L. Ling et al., A PRACTICAL ROUTE TO OPTICALLY-ACTIVE CBI, A POTENT ANALOG OF THE CC-1065 ALKYLATION SUBUNIT, Heterocyclic communications, 3(5), 1997, pp. 405-408
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocyclic communications → ACNP
ISSN journal
07930283
Volume
3
Issue
5
Year of publication
1997
Pages
405 - 408
Database
ISI
SICI code
0793-0283(1997)3:5<405:APRTOC>2.0.ZU;2-I
Abstract
A 1,2,9,9a-tetrahydrocycloprop [c]benz[e]indol-4-one, CBI precursor, r acemic 3 was resolved by Lipase PS catalyzed hydrolysis in water-satur ated isopropyl ether. A practical route for the synthesis of optically active CBI, a potent analog of the CC-1065 pharmacophore, starting fr om the resolved material was thereby developed.