PREPARATION AND USE OF TRITIATED SCHWARTZ REAGENT (ZRCP2CL3H)

Authors
ZIPPI EM ANDRES H MORIMOTO H WILLIAMS PG
Citation
Em. Zippi et al., PREPARATION AND USE OF TRITIATED SCHWARTZ REAGENT (ZRCP2CL3H), Synthetic communications, 24(7), 1994, pp. 1037-1044
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
24
Issue
7
Year of publication
1994
Pages
1037 - 1044
Database
ISI
SICI code
0039-7911(1994)24:7<1037:PAUOTS>2.0.ZU;2-A
Abstract
Treatment of Li3H with ZrCp2Cl2 in THF affords ZrCp2Cl3H. By the actio n of ZrCp2Cl3H on an acetylene, it is possible to stereo- and regiosel ectively introduce tritium into the vinylic position, a site which has often proved to be metabolically stable in complex molecules. In addi tion, ZrCp2Cl3H may be used to regioselectively label olefins with tri tium.