MODIFICATION OF POSTRADIATIVE CHANGES OF NUCLEIC-ACIDS BY THE BACTERIAL EXTRACT BRONCHO-VAXOM IN RAT-TISSUES

We have studied the influence of immuno-modulator Broncho-Vaxom on the concentration and the total content of RNA and DNA in the bone marrow , spleen and regenerating liver (after partial hepatectomy) in rats ir radiated with doses of 3 Gy, 6 Gy or 9 Gy of gamma radiation. Animals in all groups were partially hepatectomized (2/3 of liver mass removed ) within 30 min or on the 6th and 13th day after irradiation and they were examined 30 h after resection, i.e., on the 1st, 7th and 14th day after irradiation. Broncho-Vaxom was administered intraperitoneally a t the dose of 1.5 mg/rat 24 h before irradiation. We have found that a dministration of Broncho-Vaxom decreased the loss of RNA and DNA induc ed by radiation in the bone marrow and partly also in the spleen of ra ts irradiated with doses 3 and 6 Gy over the whole examined period wit h a maximum on the 14th day after irradiation. The effect of Broncho-V axom was less noticeable in the regenerating liver and appeared especi ally on the 7th day after irradiation.