Ll. Rodriguez et al., MOLECULAR INVESTIGATION OF A MULTISOURCE OUTBREAK OF CRIMEAN-CONGO HEMORRHAGIC-FEVER IN THE UNITED-ARAB-EMIRATES, The American journal of tropical medicine and hygiene, 57(5), 1997, pp. 512-518
Citations number
24
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
During the investigation of an outbreak of Crimean-Congo hemorrhagic f
ever (CCHF) in the United Arab Emirates (UAE) between 1994 and 1995, b
lood samples from suspected CCHF cases and ticks collected from livest
ock were tested for CCHF virus by antigen-capture ELISA and by a rever
se transcription-polymerase chain reaction. Phylogenetic analysis of p
artial small (S) segment nucleotide sequences from four ticks and five
human samples showed that with one exception, all the human and tick
viruses clustered along with samples from Pakistan and Madagascar in o
ne distinct lineage. Within this lineage, sequences from the UAE patie
nts were identical or closely related to those from three Hyalomma spp
. ticks obtained from livestock recently imported from Somalia. Anothe
r sequence from a UAE patient was more closely related to a CCHF virus
from Nigeria. These data indicate that the 1994-1995 CCHF epidemic in
the UAE was a multisource outbreak possibly associated with importati
on of CCHF virus-infected livestock and ticks.