Jg. Piper et al., SPHENOID WING MENINGIOMA PROGRESSION AFTER PLACEMENT OF A SUBCUTANEOUS PROGESTERONE AGONIST CONTRACEPTIVE IMPLANT, Neurosurgery, 34(4), 1994, pp. 723-725
A CAUSAL RELATIONSHIP between sex steroids and meningioma proliferatio
n has long been suspected. We report a case of the clinical progressio
n of a sphenoid wing meningioma after the placement of Norplant, a sub
cutaneous contraceptive implant containing levonorgestrel, a progester
one agonist. Although not proof of causation, this observation lends f
urther credence to the importance of progesterone receptors in the gro
wth and possible treatment of meningiomas.