VASOPRESSIN-INDUCED AMBER-LIKE SKIN NECROSIS

Case reports about vasopressin-induced cutaneous necrosis are not freq uent. Here we report a further case, of which skin manifestations incl uded not only mottling, cyanosis, ecchymosis, bullae and gangrene, but also amber-like change in focal areas. Besides, intermittent paling o f the skin with or without deep pain sensation of the limbs over non-i njection sites was observed that might be a warning sign of impending skin necrosis. Based on the literature about vasopressin-induced skin necrosis we discuss the possible role of coagulation enhancement of th is molecule.