Edible tissues of food animals may contain residues of chemical substa
nces harmful to human health, including animal drugs, mycotoxins and e
nvironmental contaminants. Current meat inspection activities rely mai
nly on visual inspection of the carcass and its offals at the slaughte
rhouse, and fail to detect chemical residues and enteric pathogens tha
t are considered as major health risks associated with meat consumptio
n. In contrast to traditional approaches, application of the hazard an
alysis critical control point (HACCP) to meat production and inspectio
n, constitutes the best alternative to reduce the incidence of residue
s and to improve meat safety. Application of HACCP to meat inspection
virtually eliminates the need for finished product testing by identify
ing the safety risks inherent in the meat production steps, from farm
to table, and devising preventive measures which can be monitored in o
rder to control the process. Accordingly, there is also a need for the
development and application of analytical methods of enough sensitivi
ty that allow real-time monitoring of chemical residues in live animal
s and their tissues.