VARIABILITY ANALYSIS OF HIV-1 GP120 V3 REGION .1. POINT ESTIMATORS FOR THE AMINO-ACID DISTRIBUTION CHARACTERISTICS

Citation
My. Shchelkanov et al., VARIABILITY ANALYSIS OF HIV-1 GP120 V3 REGION .1. POINT ESTIMATORS FOR THE AMINO-ACID DISTRIBUTION CHARACTERISTICS, Journal of biomolecular structure & dynamics, 15(2), 1997, pp. 217-229
Citations number
33
Categorie Soggetti
Biophysics,Biology
ISSN journal
07391102
Volume
15
Issue
2
Year of publication
1997
Pages
217 - 229
Database
ISI
SICI code
0739-1102(1997)15:2<217:VAOHGV>2.0.ZU;2-G
Abstract
Enumerating procedure for symbol sequences is proposed. Relationship b etween Hamming distance for symbol sequences and Euclidean distance fo r corresponding enumerations is established, and more universal Hammin g-transformed Euclidean measure is constructed. A distribution functio n of amino acid substitutions and some of its point estimators (consen sus, subconsensus, sample mean, sample central moments and asymmetry c oefficient) are introduced. Hamming-transformed Euclidean measures bet ween consensuses, subconsensuses and sample means for ten HIV-1 taxons of gp120 V3 regions are calculated. It is demonstrated that these tax ons have a complicated pattern which is significant for their classifi cation.