El. Murphy et al., INCREASED PREVALENCE OF INFECTIOUS-DISEASES AND OTHER ADVERSE OUTCOMES IN HUMAN T-LYMPHOTROPIC VIRUS TYPE-I-INFECTED AND TYPE-II-INFECTED BLOOD-DONORS, The Journal of infectious diseases, 176(6), 1997, pp. 1468-1475
Disease associations of human T lymphotropic virus types I and II (HTL
V-I and -II) infection were studied in 154 HIV-I-infected, 387 HTLV-II
-infected, and 799 uninfected blood donors. Adjusted odds ratios (ORs)
and 99% confidence intervals (CIs) were derived from logistic regress
ion models controlling for demographics and relevant confounders. All
subjects were human immunodeficiency virus type l-seronegative, HTLV-I
I was significantly associated with a history of pneumonia (OR, 26; 99
% CI, 1.2-5.3), minor fungal infection (OR, 2.9; 99% CI, 1.2-7.1), and
bladder or kidney infection (OR, 1.6; 99% CI, 1.0-2.5) within the pas
t 5 years and with a lifetime history of tuberculosis (OR, 3.9; 99% CI
, 1.3-11.6) and arthritis (OR, 1.8; 99% CI, 1.2-2.9). Lymphadenopathy
(greater than or equal to 1 cm) was associated with both HTLV-I (OR, 6
.6; 99% CI, 2.2-19.2) and HTLV-II (OR, 2.8; 99% CI, 1.1-7.1) infection
, although no case of adult T cell leukemia/lymphoma was diagnosed. Ur
inary urgency and gait disturbance were associated with both viruses.
This new finding of increased prevalence of a variety of infections in
HTLV-II-positive donors suggests immunologic impairment.