REGIOSELECTIVELY CARBAMOYLATED POLYSACCHARIDES FOR THE SEPARATION OF ENANTIOMERS IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

The chromatographic behavior of new chiral stationary phases (CSPs) ba sed on mixed substituted cellulose, amylose or amylopectin is reported . Most CSPs have a 3,5-dimethylphenylcarbamate at the 2 and 3 position s of the glucose unit and either an (R)-, (S)- or (RS)-phenylethylcarb amate at the 6 position. This study shows that configuration of the ph enylethylcarbamate at the 6 position largely influences the chiral rec ognition depending upon the polysaccharide studied. Some of the new CS Ps exhibit a better enantioselective power for several racemates as co mpared to the corresponding symmetrical substituted polysaccharides CS Ps. The resolution of some benzodiazepines is also reported. (C) 1997 Elsevier Science B.V.