Zolmitriptan (Zomig(TM), formerly 311C90) is a novel, oral antimigrain
e drug that is consistently effective and well tolerated in the acute
treatment of migraine headache and its associated symptoms. The purpos
e of this article is to review data available from pharmacological and
clinical trials with zolmitriptan and to summarize the clinically rel
evant features that distinguish this agent. We will review the attribu
tes desirable in a migraine drug and use this as a template for assess
ing zolmitriptan. Zolmitriptan provides a new oral treatment option fo
r physicians which should help improve patient outcomes.