EVALUATION OF CYTOKINES IN CEREBROSPINAL-FLUID FROM PATIENTS WITH MOYAMOYA-DISEASE

We investigated the levels of angiogenic growth factors in cerebrospin al fluid (CSF) from patients with Moyamoya disease and from those with atherosclerotic occlusive disease to evaluate the relationship of the se factors to the pathogenesis of Moyamoya disease. CSF from Moyamoya patients contained significantly higher concentrations of basic fibrob last growth factor (b-FGF) (P < 0.05). The b-FGF level was apparently elevated in patients with well developed neovascularization after indi rect revascularization surgery (P < 0.01). The other angiogenic factor s were not significantly elevated compared with those of the control g roup. (C) 1997 Elsevier Science B.V.