DISPROPORTION OF CEREBRAL SURFACE-AREAS AND VOLUMES IN CEREBRAL DYSGENESIS - MRI-BASED EVIDENCE FOR CONNECTIONAL ABNORMALITIES

In the normal adult human brain, there are quantitative relationships between a surface area I?measure of the grey matter and the volume of hemispheric grey matter the volume of the hemispheric subcortical matt er and the cross-sectional area of the corpus callosum as revealed by analysis of high resolution MRI data. These relationships reflect stru ctural order in, and biological features of normal human cerebral hemi spheres. Cerebral dysgenesis (CD) is associated with disruption of the normal organization of the hemispheres to a greater or lesser extent and is often manifest as refractory epilepsy. We have examined structu ral proportions and their disruption in the brains of patients with ep ilepsy and CD. We found that structural measures were abnormal in 60% of patients with CD, with abnormalities in 64% of hemispheres that, on visual inspection alone, appeared completely normal. We showed that t he disruptions found are compatible with expected histopathology in ca ses where histopathology may be predictable, and that extensive abnorm alities may be due to abnormal patterns of connections within the hemi spheres. In some cases, it may be possible to predict histopathology o n the basis of quantitative analyses of high resolution MRI data, wize n such prediction is not possible on visual inspection alone.