X-CHROMOSOME MAP AT 75-KB STS RESOLUTION, REVEALING EXTREMES OF RECOMBINATION AND GC CONTENT

Authors
NAGARAJA R MACMILLAN S KERE J JONES C GRIFFIN S SCHMATZ M TERRELL J SHOMAKER M JERMAK C HOTT C MASISI M MUMM S SRIVASTAVA A PILIA G FEATHERSTONE T MAZZARELLA R KESTERSON S MCCAULEY B RAILEY B BUROUGH F NOWOTNY V DURSO M STATES D BROWNSTEIN B SCHLESSINGER D
Citation
R. Nagaraja et al., X-CHROMOSOME MAP AT 75-KB STS RESOLUTION, REVEALING EXTREMES OF RECOMBINATION AND GC CONTENT, PCR methods and applications, 7(3), 1997, pp. 210-222
Citations number
51
Categorie Soggetti
Biothechnology & Applied Migrobiology",Biology
Journal title
PCR methods and applications → ACNP
ISSN journal
10549803
Volume
7
Issue
3
Year of publication
1997
Pages
210 - 222
Database
ISI
SICI code
1054-9803(1997)7:3<210:XMA7SR>2.0.ZU;2-#
Abstract
A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large -insert clones that are cross-validated as sequencing substrates acros s the chromosome. Marker density also permits estimates of regional ge ne content and a detailed comparison of genetic and physical map dista nces. Five regions are detected with relatively high G + C correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.