LATENTIATION OF CHEMOTHERAPEUTICS AGENTS .2. SYNTHESIS OF OXIDIZED CELLULOSE IMINE DERIVATIVES WITH ANTIMALARIALS

Oxidized cellulose derivatives with sulfonamides and sulfone were synt hesized in order to obtain antimalarials better than the now available . Derivatives of dapsone (ML14), sulfadiazine (ML17), sulfamethoxazole (ML18), sulfisoxazole (ML19), sulfamethoxypiridazine (ML20), sulfamet er (ML22) were identified by usual spectrometric analysis (IR, UV, H-1 -NMR). Submitted to preliminar biological assay, only three compounds avoided the parasitemia on the 5th day after treatment and of these, s ulfadiazine derivative showed activity on the 30th day after treatment of mice infected with Plasmodium berghei.