Ml. Cruz et al., LATENTIATION OF CHEMOTHERAPEUTICS AGENTS .2. SYNTHESIS OF OXIDIZED CELLULOSE IMINE DERIVATIVES WITH ANTIMALARIALS, Starke, 49(2), 1997, pp. 66-70
Oxidized cellulose derivatives with sulfonamides and sulfone were synt
hesized in order to obtain antimalarials better than the now available
. Derivatives of dapsone (ML14), sulfadiazine (ML17), sulfamethoxazole
(ML18), sulfisoxazole (ML19), sulfamethoxypiridazine (ML20), sulfamet
er (ML22) were identified by usual spectrometric analysis (IR, UV, H-1
-NMR). Submitted to preliminar biological assay, only three compounds
avoided the parasitemia on the 5th day after treatment and of these, s
ulfadiazine derivative showed activity on the 30th day after treatment
of mice infected with Plasmodium berghei.