Objectives. Standardized estimates of the prevalence of substance use
by runaway and homeless youth between the ages of 12 and 21 in various
settings were compared with each other and with estimates for youth i
n the general population. Methods. Four surveys were used: (1) a natio
nally representative survey of runaway and homeless youth residing in
federally and nonfederally funded shelters; (2) a multicity survey of
street youth; (3) a nationally representative household survey of yout
h with and without recent runaway and homeless experiences; and (4) a
nationally representative household survey of youth whose previous run
away/homeless status was unknown. Results. For almost every substance,
substance use prevalence was highest among street youth. Shelter yout
h and household youth with recent runaway/homeless experiences reporte
d similar rates. In the household surveys, substance use rates were lo
west and were generally comparable. Conclusions. Many homeless and run
away youth use tobacco, alcohol, and other drugs at rates substantiall
y higher than nonrunaway and nonhomeless youth, indicating a need for
comprehensive and intensive substance abuse prevention and treatment s
ervices for these youth.