OBJECTIVE To provide evidence-based answers to clinical questions pose
d by family physicians about Group A streptococcus pharyngitis and to
further understanding of why management is controversial. QUALITY OF E
VIDENCE Evidence from randomized trials was not found for most questio
ns. The most critical information came from high-quality community pre
valence studies and criterion standard studies of physician clinical j
udgment. MAIN FINDINGS Expert recommendations for physician management
are not likely to help prevent rheumatic fever, as most people with s
ore throats do not seek medical care. Current clinical practices resul
t in overuse of antibiotics because accuracy of clinical judgment is l
imited. CONCLUSIONS Costs associated with visits for upper respiratory
infections as well as increasing antibiotic resistance necessitate re
considering the current clinical approach. An alternative management s
trategy is presented in part 2.