A malignant rhabdoid tumor of the brain from a 19-month-old child was
studied. Two related clones, ,-8,+der(8)t(8;22)(p11;q?12)X2,-22,del(22
)(q12?13) and 46,XX-8,+der(8)t(8;22)(p11;q?12)X2,-22,r(22) were found
after chromosome analyses of primary and recurrent tumor, and multiple
nude mouse passages of the tumor. Breakpoints were studied using FISH
. (C) Elsevier Science Inc., 1997.