CYTOGENETIC ANALYSIS OF SEVERAL PSEUDOMYXOMA PERITONEI LESIONS ORIGINATING FROM A MUCINOUS CYSTADENOMA OF THE APPENDIX

Epithelial proliferative lesions of the appendix are rare and have nev er been studied cytogenetically. We present the chromosomal banding an alysis of four successfully short-term cultured samples from pseudomyx oma peritonei lesions originating from a cystadenoma of the appendix. All four samples contained clonal chromosome abnormalities. In three o f them, the clone 46,XX,der(6)?del(6)(q16q21)? del(6)(q27) was found, whereas a clone with the karyotype 46,XX,t(2;17)(p21;p13),t(6;12)(p21; q13), t(12;q15)(q24;q15) was detected in the fourth sample. Our findin gs support the view that pseudomyxoma peritonei originates by spreadin g from a primary mucinous neoplasm of an intraperitoneal organ rather than through mucinous metaplasia or multifocal primary neoplastic tran sformation of the peritoneum. (C) Elsevier Science Inc., 1997.