REACTION OF 4-ETHOXYCARBONYL-2-PHENYL-4,5-DIHYDROOXAZOL-5-ONE WITH ORGANOLEAD(IV) TRIACETATES - A ROUTE TO SOME ALPHA-ARYLGLYCINE AND ALPHA-VINYLGLYCINE DERIVATIVES

Authors
KOEN MJ MORGAN J PINHEY JT SHERRY CJ
Citation
Mj. Koen et al., REACTION OF 4-ETHOXYCARBONYL-2-PHENYL-4,5-DIHYDROOXAZOL-5-ONE WITH ORGANOLEAD(IV) TRIACETATES - A ROUTE TO SOME ALPHA-ARYLGLYCINE AND ALPHA-VINYLGLYCINE DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (4), 1997, pp. 487-491
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
4
Year of publication
1997
Pages
487 - 491
Database
ISI
SICI code
0300-922X(1997):4<487:RO4WO>2.0.ZU;2-T
Abstract
4-Ethoxycarbonyl-2-phenyl-4,5-dihydrooxazol-5-one undergoes rapid aryl ation and vinylation with arylead triacetates and (E)-styryllead triac etates, respectively. The resulting moisture-sensitive 4-aryl- and 4-s tyryl-oxazolones undergo hydrolysis and decarboxylation under mild Con ditions to provide a short efficient route to derivatives of alpha-ary lglycines and alpha-vinylglycines.