THE SYNTHESIS OF 3-PHOSPHONOCYCLOBUTYL AMINO-ACID-ANALOGS OF GLUTAMIC-ACID VIA DIETHYL 3-OXYCYCLOBUTYLPHOSPHONATE, A VERSATILE SYNTHETIC INTERMEDIATE

Authors
HANRAHAN JR TAYLOR PC ERRINGTON W
Citation
Jr. Hanrahan et al., THE SYNTHESIS OF 3-PHOSPHONOCYCLOBUTYL AMINO-ACID-ANALOGS OF GLUTAMIC-ACID VIA DIETHYL 3-OXYCYCLOBUTYLPHOSPHONATE, A VERSATILE SYNTHETIC INTERMEDIATE, Journal of the Chemical Society. Perkin transactions. I, (4), 1997, pp. 493-502
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
4
Year of publication
1997
Pages
493 - 502
Database
ISI
SICI code
0300-922X(1997):4<493:TSO3AO>2.0.ZU;2-Y
Abstract
A range of novel 3-phosphonocyclobutyl amino acids have been prepared via the versatile synthetic intermediate, diethyl 3-oxocyclobutylphosp honate, which is prepared in three steps from diethyl methylphosphonat e. Elaboration of the 3-oxo functionality readily facilitates the synt hesis of the 3-phosphonocyclobutyl amino acids.