DIPEPTIDES BEARING NUCLEOBASES FOR THE SYNTHESIS OF NOVEL PEPTIDE NUCLEIC-ACIDS

Authors
LOWE G VILAIVAN T
Citation
G. Lowe et T. Vilaivan, DIPEPTIDES BEARING NUCLEOBASES FOR THE SYNTHESIS OF NOVEL PEPTIDE NUCLEIC-ACIDS, Journal of the Chemical Society. Perkin transactions. I, (4), 1997, pp. 547-554
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
4
Year of publication
1997
Pages
547 - 554
Database
ISI
SICI code
0300-922X(1997):4<547:DBNFTS>2.0.ZU;2-8
Abstract
Three stereoisomers (cis-L, trans-D and cis-D) of N-Fmoc-glycyl-4-(thy min-1-yl)proline and their pentafluorophenyl esters have been prepared for use in the synthesis of novel peptide nucleic acids. In addition, N-Fmoc-glycyl-4(N-6-benzoyladenin-9-yl)proline, N-Fmoc-glycyl-4-(N-4- benzoylcytosin-1-yl)proline and N-Fmoc-glycyl-4-(N-2-isobutyrylguanin- 9-yl)proline and their pentafluorophenyl esters of the cis-D series ha ve been synthesized.