SOLID-PHASE SYNTHESIS OF NOVEL PEPTIDE NUCLEIC-ACIDS

Novel peptide nucleic acids with configurationally and conformationall y constrained glycylproline backbones have been synthesized by the sol id-phase method from the Fmoc-protected dipeptide building blocks. Thr ee decathymine peptide nucleic acids with different stereochemistry at the proline ring (cis-L, trans-D, cis-D) and mixed sequences in the c is-D series have been efficiently synthesized. In addition, oligothymi ne peptide nucleic acids with a conformationally flexible glycyl-N-eth ylglycine backbone have also been synthesized from stepwise coupling o f the Boc-protected monomer.