DETERMINANTS OF LIFE-SPAN AFTER KASAI OPERATION AT THE ERA OF LIVER-TRANSPLANTATION

Citation
F. Gauthier et al., DETERMINANTS OF LIFE-SPAN AFTER KASAI OPERATION AT THE ERA OF LIVER-TRANSPLANTATION, Tohoku Journal of Experimental Medicine, 181(1), 1997, pp. 97-107
Citations number
24
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
00408727
Volume
181
Issue
1
Year of publication
1997
Pages
97 - 107
Database
ISI
SICI code
0040-8727(1997)181:1<97:DOLAKO>2.0.ZU;2-9
Abstract
The aim of this work is to determine the influence of age, extrahepati c biliary lesions pattern (EHBP) and association to polysplenia syndro me (PS) on 10 years outcome of 164 patients with biliary atresia (BA) treated from 1984 to 1992 by initial Kasai operation (KO) and secondar y liver transplantation (LT) when necessary. Actuarial crude survival without or after LT(CS), actuarial survival with native liver (NLS) an d jaundice-free actuarial survival with native liver (JFS) were calcul ated from 1 to 10 years versus age (under/over 45 days), EHBP (favorab le/unfavorable) and PX (no/yes). Overall 10-year CS is 70%, overall 10 -year NLS and JFS are 14%. In univariate analysis, age at KO under 46 days, favorable EHBP (BA with patent gallbladder, and/or cystic dilata tion of extrahepatic bile duct, or BA restricted to choledocus), and a bsence of PS are significant determinants of a better outcome regardin g CS, NLS and JFS. EHBP is more discriminant than age. Influence of PX in this series is redundant with that of EHBP since 11/11 patients wi th PS had unfavorable EHBP.