CLINICAL-SIGNIFICANCE OF TC-99M-DTPA GALACTOSYL HUMAN SERUM-ALBUMIN SCINTIGRAM IN FOLLOW-UP AFTER KASAI OPERATION

The scintigram using (99m)Technetium-DTPA galactosyl human serum album in (Tc-99m-GSA) which binds to asialoglycoprotein receptors on hepatoc ytes is a good index of hepatocyte function in various liver diseases in adult patients. In 43 patients (4 months to 30 years old) who had u ndergone Kasai procedure. we performed 53 series of (TC)-T-99m-GSA sci ntigrams and checked the laboratory data of blood draw and the clinica l status. The indices for blood clearance and liver accumulation were evaluated on the basis of the dynamic data after Tc-99m-GSA injection. HH15 as an index of the blood clearance, and LHL15 as an index of the accumulation of the hepatocytes were calculated and the HH15/LHL15 ra tio (H/L15) was examined. Tc-99m-GSA scintigram correlated with liver function and clinical status. Our results revealed that 1) The deterio ration of the liver functions and clinical status correlates proportio nally with H/L15, 2) The results of (99m)Technetium-GSA scintigram cor relate with several liver function tests, especially direct bilirubin, albumin and choline esterase, 3) This scintigram is an useful index o f clinical status and hepatic function as well as the change of the he patic parenchymal reserve in BE patients, especially for the evaluatio n of liver transplantation.