Abr. Thomson et G. Wild, ADAPTATION OF INTESTINAL NUTRIENT TRANSPORT IN HEALTH AND DISEASE .2., Digestive diseases and sciences, 42(3), 1997, pp. 470-488
The first part of this review dealt with the physiology of glucose tra
nsport with specific emphasis on transporters of the brush border memb
rane (BBM) and the basolateral membrane (BLM). On the BBM: the sodium
(Na)/glucose transporters (SGLT1 and SGLT2), the Na-independent transp
orter (GLUTS) and on the BLM the hexose transporter (GLUT2) are discus
sed. The molecular biology of these transporters is also reviewed, In
the second part of the review, we discuss the manner in which intestin
al adaptation may be modified by alterations in the diet, especially t
he lipid constituents, and two important examples of intestinal adapta
tion will be given: diabetes mellitus and inflammatory bowel disease.