STRUCTURE-ACTIVITY RELATIONSHIP IN THE INDUCTION OF CHROMOSOMAL-ABERRATIONS AND SPINDLE DISTURBANCES IN CHINESE-HAMSTER EPITHELIAL LIVER-CELLS BY REGIOISOMERIC PHENANTHRENE QUINONES

Authors
TURCHI G GLATT HR SEIDEL A PULITI A SBRANA I
Citation
G. Turchi et al., STRUCTURE-ACTIVITY RELATIONSHIP IN THE INDUCTION OF CHROMOSOMAL-ABERRATIONS AND SPINDLE DISTURBANCES IN CHINESE-HAMSTER EPITHELIAL LIVER-CELLS BY REGIOISOMERIC PHENANTHRENE QUINONES, Cell biology and toxicology, 13(3), 1997, pp. 155-165
Citations number
43
Categorie Soggetti
Cell Biology",Toxicology
Journal title
Cell biology and toxicology → ACNP
ISSN journal
07422091
Volume
13
Issue
3
Year of publication
1997
Pages
155 - 165
Database
ISI
SICI code
0742-2091(1997)13:3<155:SRITIO>2.0.ZU;2-F
Abstract
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated fo r their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromos omal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virt ually inactive in this respect. However, all four compounds enhanced t he frequency of c-mitoses.