L. Michaux et al., T(14-19) BCL3 REARRANGEMENTS IN LYMPHOPROLIFERATIVE DISORDERS - A REVIEW OF 23 CASES/, Cancer genetics and cytogenetics, 94(1), 1997, pp. 36-43
The t(14;19)(q32.3;q13.2) is a rare but recurrent translocation found
in patients with B-cell malignancies, mainly in chronic B-cell lymphop
roliferative disorders. When occurring in chronic lymphocytic leukemia
(CLL), atypical lymphocyte morphology and immunophenotype have been r
eported. A high proportion of patients with CLL and t(14;19) are aged
less than 40 years. t(14;19) is often associated with rapidly progress
ive disease, and overall prognosis is poor compared to the expected su
rvival in chronic lymphocytic leukemia and low-grade B-cell lymphoma.
t(14;19) is rarely the sole cytogenetic aberration. Trisomy 12 is the
most frequent associated abnormality, and is observed in 50% of cases.
t(14;19) involves the BCL3 gene, which is located at the breakpoint o
n chromosome 19 and is juxtaposed to the immunoglobulin heavy chain ge
ne locus on chromosome 14 (often in the switch alpha region) in a ''he
ad-to-head'' configuration. The translocation does not interrupt the t
ranscriptional integrity of BCL3, but is associated with overexpressio
n of this gene, which encodes an I kappa B-like protein and modulates
the activity of the NF-kappa B transcription factors. The genes affect
ed by overexpression of BCL3 remain to be identified. (C) Elsevier Sci
ence, Inc., 1997.