FACILE 1,2-ARYL MIGRATION OF 2-HALOMETHYL-2-(4'-HYDROXYPHENYL) KETALS- A NOVEL SINGLE-STEP SYNTHESIS OF 4-HYDROXYPHENYLACETIC ACID AND ITSDERIVATIVES

Authors
KUMAR A RANE RA RAVINDRAN VK DIKE SY
Citation
A. Kumar et al., FACILE 1,2-ARYL MIGRATION OF 2-HALOMETHYL-2-(4'-HYDROXYPHENYL) KETALS- A NOVEL SINGLE-STEP SYNTHESIS OF 4-HYDROXYPHENYLACETIC ACID AND ITSDERIVATIVES, Synthetic communications, 27(7), 1997, pp. 1133-1141
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
7
Year of publication
1997
Pages
1133 - 1141
Database
ISI
SICI code
0039-7911(1997)27:7<1133:F1MO2K>2.0.ZU;2-N
Abstract
1,2-Aryl migration of 1-halomethyl-2-(4-hydroxyphenyl) ketals, obtaine d from 2-bromoethyl 4-hydroxyacetophenone, under mild basic conditions have been shown to give 4-hydroxyphenylacetic acidor its derivtives w hich are key intermediates in the preparation of Atenolol, a well know n cardiac beta-blocker.