NEW HETEROOLIGOMERIC PEPTIDE NUCLEIC-ACIDS WITH IMPROVED BINDING-PROPERTIES TO COMPLEMENTARY-DNA

Authors
JORDAN S SCHWEMLER C KOSCH W KRETSCHMER A STROPP U SCHWENNER E MIELKE B
Citation
S. Jordan et al., NEW HETEROOLIGOMERIC PEPTIDE NUCLEIC-ACIDS WITH IMPROVED BINDING-PROPERTIES TO COMPLEMENTARY-DNA, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 687-690
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
6
Year of publication
1997
Pages
687 - 690
Database
ISI
SICI code
0960-894X(1997)7:6<687:NHPNWI>2.0.ZU;2-X
Abstract
Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger bindi ng to complementary DNA than the original PNAs, and are consequently v ery interesting candidates as antisense compounds for applications in therapy and in diagnostics. (C) 1997 Elsevier Science Ltd.