ENZYMATIC-SYNTHESIS OF PEPTIDYL AMINO-ALCOHOLS AND PEPTIDYL AMINO ALDEHYDES-SERINE PROTEINASE-INHIBITORS

Authors
POTETINOVA JV VOYUSHINA TL STEPANOV VM
Citation
Jv. Potetinova et al., ENZYMATIC-SYNTHESIS OF PEPTIDYL AMINO-ALCOHOLS AND PEPTIDYL AMINO ALDEHYDES-SERINE PROTEINASE-INHIBITORS, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 705-710
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
6
Year of publication
1997
Pages
705 - 710
Database
ISI
SICI code
0960-894X(1997)7:6<705:EOPAAP>2.0.ZU;2-C
Abstract
An enzymatic synthesis of peptidyl amino alcohols is described. The re actions were performed in organic solvents using as a catalyst subtili sin distributed on the surface of macroporous silica. Subsequent mild oxidation of peptidyl amino alcohols results in peptide aldehydes - th e potent specific inhibitors of serine proteinases. (C) 1997 Elsevier Science Ltd.