SULFONOPEPTIDE INHIBITORS OF LEUKOCYTE ADHESION

Authors
CARSON KG SCHWENDER CF SHROFF HN COCHRAN NA GALLANT DL BRISKIN MJ
Citation
Kg. Carson et al., SULFONOPEPTIDE INHIBITORS OF LEUKOCYTE ADHESION, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 711-714
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
6
Year of publication
1997
Pages
711 - 714
Database
ISI
SICI code
0960-894X(1997)7:6<711:SIOLA>2.0.ZU;2-8
Abstract
The amino acid sequence L-D-T-S-L has been shown to be a significant r ecognition motif involved in the interaction of integrin alpha(4) beta (7) with its endothelial ligand, MAdCAM-1. Based on the known active p eptide, a series of sulfonamide peptidomimetics was synthesized. Sulfo nopeptide 2, Ac-L-Psi D-V-NH2, was shown to inhibit leukocyte adhesion . (C) 1997 Elsevier Science Ltd.