The amino acid sequence L-D-T-S-L has been shown to be a significant r
ecognition motif involved in the interaction of integrin alpha(4) beta
(7) with its endothelial ligand, MAdCAM-1. Based on the known active p
eptide, a series of sulfonamide peptidomimetics was synthesized. Sulfo
nopeptide 2, Ac-L-Psi D-V-NH2, was shown to inhibit leukocyte adhesion
. (C) 1997 Elsevier Science Ltd.