VASOPRESSIN TRISULFIDE - SYNTHESIS, NMR-STUDY AND AFFINITY STUDIES WITH V-1 AND V-2 SUBTYPES RECEPTORS

Authors
MOUTIEZ M LIPPENS G SERGHERAERT C TARTAR A
Citation
M. Moutiez et al., VASOPRESSIN TRISULFIDE - SYNTHESIS, NMR-STUDY AND AFFINITY STUDIES WITH V-1 AND V-2 SUBTYPES RECEPTORS, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 719-724
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
6
Year of publication
1997
Pages
719 - 724
Database
ISI
SICI code
0960-894X(1997)7:6<719:VT-SNA>2.0.ZU;2-E
Abstract
A trisulfide-containing analogue of [arginine(8)]-vasopressin has been synthesized from the corresponding dithiol derivative. Affinities for V1 and V2 receptors were determined. Characterization of the structur al differences with the parent hormone was achieved by NMR analysis an d a model was built from the disulphide derivative. (C) 1997 Elsevier Science Ltd.