BETA-AMINO ACID-DERIVATIVES AS ORALLY-ACTIVE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS

Authors
KOTTIRSCH G ZERWES HG COOK NS TAPPARELLI C
Citation
G. Kottirsch et al., BETA-AMINO ACID-DERIVATIVES AS ORALLY-ACTIVE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 727-732
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
6
Year of publication
1997
Pages
727 - 732
Database
ISI
SICI code
0960-894X(1997)7:6<727:BAAONF>2.0.ZU;2-2
Abstract
The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid f unction and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally acti ve antagonists of the platelet fibrinogen receptor GPIIb/IIIa. (C) 199 7 Elsevier Science Ltd.