AN HIV-1 INFECTION-RELATED IDIOTYPE CLONOTYPE (1F7) IS EXPRESSED ON ANTIBODIES DIRECTED TO ENVELOPE GLYCOPROTEIN IN SIMIAN IMMUNODEFICIENCYVIRUS-INFECTED RHESUS-MONKEYS AND CHIMERIC SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS-INFECTED RHESUS-MONKEYS/
S. Muller et al., AN HIV-1 INFECTION-RELATED IDIOTYPE CLONOTYPE (1F7) IS EXPRESSED ON ANTIBODIES DIRECTED TO ENVELOPE GLYCOPROTEIN IN SIMIAN IMMUNODEFICIENCYVIRUS-INFECTED RHESUS-MONKEYS AND CHIMERIC SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS-INFECTED RHESUS-MONKEYS/, Hybridoma, 16(1), 1997, pp. 17-21
An antiidiotypic/clonotypic marker, designated 1F7, is restricted to a
ntibodies directed to human immunodeficiency virus type 1 (HIV-1) enve
lope, core, and reverse transcriptase proteins, 1F7-Id is shared by mo
re than 70% of HIV-infected individuals, arising early and persisting
throughout all disease stages. To study the specificity and biological
function of this cross-reactive idiotypic marker, and to explore its
potential in therapeutics, we have sought an appropriate animal model,
1F7-Id+ antiviral antibodies are found among experimentally HIV-1(III
B)-infected chimpanzees; however, these rare and expensive animals do
not develop acquired immunodeficiency syndrome (AIDS), and so are not
an appropriate model, We now report the presence in rhesus monkeys of
1F7-Id on antibodies to the external envelope glycoproteins of simian
immunodeficiency virus (SIV), This may be surprising, in view of the g
enetic and serologic differences between SIV and HIV-1, but is in acco
rd with the occurrence of 1F7-Id on antibodies reacting with a broad r
ange of HIV-1 strains. We also found 1F7-Id on anti-gp120 antibodies i
n rhesus monkeys infected with chimeric immunodeficiency viruses (SHIV
) expressing the env, tat, and rev genes of HIV-1 on a backbone of SIV
. Both SIV and SHIV cause AIDS in these monkeys, Thus, SIV- and SHIV-i
nfected rhesus monkeys are suitable models for exploring the role of 1
F7 in AIDS pathogenesis and prevention. Experiments are underway using
MAb 1F7 to test the hypothesis of deceptive imprinting in AIDS.