The human dad-1 cDNA homolog was isolated from rice plants. The amino
acid sequence of the predicted protein product is well conserved in bo
th animals and plants. This rice dad-1 homolog can rescue the temperat
ure-sensitive dad-1 mutants of hamster cells from apoptotic death, sug
gesting that the rice dad-1 homolog also functions as a suppressor for
programmed cell death.