BIOLOGY AND THERAPY OF IMMUNOGLOBULIN DEPOSITION DISEASES

Authors
DHODAPKAR MV MERLINI G SOLOMON A
Citation
Mv. Dhodapkar et al., BIOLOGY AND THERAPY OF IMMUNOGLOBULIN DEPOSITION DISEASES, Hematology/oncology clinics of North America, 11(1), 1997, pp. 89
Citations number
110
Categorie Soggetti
Oncology,Hematology
Journal title
Hematology/oncology clinics of North America → ACNP
ISSN journal
08898588
Volume
11
Issue
1
Year of publication
1997
Database
ISI
SICI code
0889-8588(1997)11:1<89:BATOID>2.0.ZU;2-F
Abstract
Pathologic immunoglobulin deposition can lead to significant organ dys function, morbidity and mortality. This article examines the recent ad vances in the understanding of both host and protein factors in the pa thogenesis of primary systemic amyloidosis and light chain deposition disease. Limitations of current therapy are reviewed and newer approac hes including iododoxorubicin, dexamethasone, and high-dose therapy ar e discussed.