ALLOGENEIC STEM-CELL TRANSPLANTATION FOR MULTIPLE-MYELOMA

High-dose chemotherapy (with or without total body irradiation) follow ed by allogenic marrow transplantation is curative for some patients w ith advanced multiple myeloma. A relatively high transplant-related mo rtality, however, limits the wider application of this approach. The c hallenge for future studies will be to develop less toxic preparative regimens, more efficient ways to prevent infection and graft-versus-ho st disease, and methods to enhance the graft-versus-leukemia effect of allografts.