IMMUNOGENICITY OF RECOMBINANT HUMAN INTERLEUKIN-3

Authors
GUNN H
Citation
H. Gunn, IMMUNOGENICITY OF RECOMBINANT HUMAN INTERLEUKIN-3, Clinical immunology and immunopathology, 83(1), 1997, pp. 5-7
Citations number
8
Categorie Soggetti
Pathology,Immunology
Journal title
Clinical immunology and immunopathology → ACNP
ISSN journal
00901229
Volume
83
Issue
1
Year of publication
1997
Pages
5 - 7
Database
ISI
SICI code
0090-1229(1997)83:1<5:IORHI>2.0.ZU;2-K
Abstract
Most recombinant human (rh) proteins elicit an immune response in expe rimental animals. Antibodies are usually detected within 1 to 2 weeks of protein administration. The immunogenicity of rh proteins is an imp ortant aspect for both experimental and clinical investigations. The f ormation of neutralizing antibodies-as shown here for rhIL-3-reduced t he absolute bioavailability of the protein in Rhesus monkeys. (C) 1997 Academic Press.