COGNITIVE AND ADAPTIVE-BEHAVIOR 1 AND 3 YEARS FOLLOWING BONE-MARROW TRANSPLANTATION

Children receiving a bone marrow transplant (BMT) are at risk for neur opsychological late effects because of potentially neurotoxic chemothe rapy and total body irradiation, The goal of this study was to prospec tively and longitudinally assess the intellectual and adaptive functio ning of children receiving a BMT, This study examined 67 children whos e development was evaluated at baseline prior to BMT and at 1 year fol low-up, Mean age at BMT was 45 months, Repeated-measures ANOVA indicat ed a significant decline in IQ between baseline and the 1 year follow- up evaluation, Multivariate and exploratory univariate analyses examin ed the potential influence of diagnosis, treatment regimen, cranial ra diation dose, age at time of transplant, and sex of child but none of these independent variables predicted outcome, Twenty-six children (me an age at BMT of 28.4 months) were also given developmental evaluation s 3 years post-BMT, Although IQ at the 1 year follow-up was significan tly lower than baseline, no further changes were evident at the 3 year follow-up evaluation, Scores on the Vineland Adaptive Behavior Scales also dropped significantly between baseline and the 1 year follow-up, but did not change between the 1 year and 3 year evaluations.