M. Pawlikowski et J. Kunertradek, ANGIOTENSIN-IV STIMULATES THE PROLIFERATION OF RAT ANTERIOR-PITUITARY-CELLS IN-VITRO, Biochemical and biophysical research communications, 232(2), 1997, pp. 292-293
The effects of ansotensins II (A II) and IV (A IV) and of A II recepto
r antagonists losartan (Los) and PD 123319 on [H-3]-thymidine incorpor
ation into DNA of the rat anterior pituitary cells in vitro have been
studied, The anterior pituitary cells were isolated from the pituitari
es of male rats implanted chronically by diethylstilboestrol (DES). It
has been found that A IV, like A II, stimulated the tritiated thymidi
ne incorporation into pituitary cells. The effect has not been blocked
by antagonists of AT1 and AT2 receptors, Los and PD 123319, respectiv
ely. (C) 1997 Academic Press.