THE EXPRESSION OF INSECTICIDE RESISTANCE-RELATED CYTOCHROME-P450 FORMS IS REGULATED BY MOLTING HORMONE IN DROSOPHILA-MELANOGASTER

Authors
SPIEGELMAN VS FUCHS SY BELITSKY GA
Citation
Vs. Spiegelman et al., THE EXPRESSION OF INSECTICIDE RESISTANCE-RELATED CYTOCHROME-P450 FORMS IS REGULATED BY MOLTING HORMONE IN DROSOPHILA-MELANOGASTER, Biochemical and biophysical research communications, 232(2), 1997, pp. 304-307
Citations number
26
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
232
Issue
2
Year of publication
1997
Pages
304 - 307
Database
ISI
SICI code
0006-291X(1997)232:2<304:TEOIRC>2.0.ZU;2-M
Abstract
The expression and enzymatic activities of insecticide resistance-rela ted cytochrome P450B are increased by the treatment with 20-hydroxyecd ysone (20HE) in D. melanogaster Oregon R flies. We have explored the r ole of this hormone in the maintenance of P450B basal expression, Arre st of ecdysone synthesis led to a decrease in CYP6A2 mRNA level, as we ll as in P450B expression and activities, This effect occurred both in insecticide susceptible (ecd(1)) and resistant (IRED) strains carryin g the temperature-sensitive ecd mutation, The role of the 20HE in the regulation of cytochrome P450-mediated insecticide resistance has been proposed. (C) 1997 Academic Press.