Risperidone was effective in successfully treating a patient's negativ
e symptoms of schizophrenia as well as reducing adverse effects from t
ypical antipsychotic drugs. Auditory hallucinations reemerged after 8
months, however, and again after 24 months of risperidone therapy. Ree
mergence of psychotic symptoms after initial response might be explain
ed by inadequate dosage, by the natural course of the patient's schizo
phrenia independent of drug therapy, or by the possibility that, for t
his patient, risperidone was less effective than chlorpromazine for th
e positive symptom of auditory hallucinations.