PREEVACUATION SERUM CA-125 IN COMPLETE HYDATIDIFORM MOLE

Studies on CA 125 in hydatidiform mole are limited, The objective of t his study was to measure the preevacuation serum CA 125 level in patie nts with complete hydatidiform mole and to determine whether it could predict the later development of persistent trophoblastic disease, Pre evacuation serum CA 125 levels were immunoradiometrically measured in 69 patients with histologically confirmed complete hydatidiform mole, The mean (range) serum CA 125 level was 63.7 (10.5-404.7) U/ml, Using 35 U/ml as the cutoff point, the elevated CA 125 levels were observed in 53.6% (37/69) of the patients. The mean serum CA 125 level of patie nts who later developed persistent trophoblastic disease was not signi ficantly higher than that of those who had benign course (78.9 vs 52.6 U/ml, P > 0.05), In conclusion, the preevacuation serum CA 125 level was elevated in about half of patients with complete hydatidiform mole and it could not be used to predict the subsequent development of per sistent trophoblastic disease. (C) 1997 Academic Press.