Objective: Vulvar vestibulitis syndrome (VVS) is thought to be the mos
t frequent cause of dyspareunia in premenopausal women and is one of t
he major subtypes of vulvodynia. Vulvar vestibulitis is a chronic, per
sistent clinical syndrome characterized by severe pain on vestibular t
ouch or attempted vaginal entry, exquisite tenderness to a cotton-swab
palpation of the vestibular area, and physical findings confined to v
estibular erythema. The purpose of this paper is to critically review
the descriptive, diagnostic, etiologic, and treatment studies on VVS.
Methodological problems are highlighted, and future guidelines for res
earch are proposed. Data Sources: References were obtained from a MEDL
INE search covering the period from January 1984 until June 1995. The
indexing term ''vulvar vestibulitis'' was used, and the search was con
strained to English-language articles. References from other relevant
sources, such as texts and bibliographies, were also included. Study S
election: All articles pertaining to VVS were reviewed. Data Extractio
n: All data relevant to the descriptive, diagnostic, etiologic, and tr
eatment aspects of VVS were included. Data Synthesis: Pain symptomatol
ogy tends to be underemphasized in the current descriptive studies. Th
e trend in etiological research is to focus on biomedical factors such
as candidiasis and human papillomavirus (HPV). Only a few studies ado
pt a nonreductionnist approach. Surgery is the treatment option with t
he highest reported success rate. Medical management is underinvestiga
ted, considering its widespread use. Pain management techniques such a
s biofeedback and behavior therapy show promising results. Conclusions
: A pain syndrome conceptualization is suggested as the most useful ap
proach for solving current empirical and clinical problems.